Extra Super Enjofil (Sildenafil/Dapoxetine)

What is Extra Super Enjofil?

How It Works (Mechanism of Action)

Sildenafil – the erection pathway 

Dapoxetine – the ejaculation pathway 

Dosage Guide

This section cannot give you a single dose, because the product’s strength is not established. Read your pack, then apply the guidance below.

Approved dosing for each ingredient

Ingredient	Recommended dose	Maximum	Frequency
Sildenafil	50 mg	100 mg	Once in 24 hours
Dapoxetine	30 mg	60 mg	Once in 24 hours

If your pack states dapoxetine 30 mg

If your pack states dapoxetine 60 mg

If your pack states dapoxetine 100 mg

Groups where dapoxetine requires care or is excluded 

Patient Group	Guidance
Men aged 65 and over	Efficacy and safety not established
Men under 18	Not indicated
Mild to moderate renal impairment	Use with caution
Severe renal impairment	Not recommended
Moderate to severe hepatic impairment	Contraindicated
Taking potent CYP3A4 inhibitors	Contraindicated
Taking moderate CYP3A4 inhibitors	Restricted to 30 mg
Taking any PDE-5 inhibitor	Should not be used

How to Take It

Precautions

Absolute Contraindications – Do Not Use If You

From the sildenafil product information: 

From the dapoxetine product information – frequently overlooked: 

Conditions to Disclose to Your Doctor

Tell your doctor before use if you have or had:

Also disclose every medicine, supplement, and herbal product you take.

Food, Drink, and Lifestyle Precautions

Item	Effect	Recommendation
Alcohol	May increase neurocognitive effects and enhance syncope risk, raising the chance of accidental injury	Avoid entirely
Recreational drugs with serotonergic activity	Ketamine, MDMA and LSD may cause arrhythmia, hyperthermia, and serotonin syndrome	Avoid entirely
Recreational drugs with sedative properties	Narcotics and benzodiazepines may increase somnolence and dizziness	Avoid entirely
High-fat meals	Delay sildenafil onset; Tmax +60 min, Cmax −29%	Take after a light meal
Grapefruit juice	CYP3A4 inhibitor; raises levels of both drugs	Avoid on dosing days
Water	Reduces fainting risk through hydration	Drink a full glass with the tablet
Driving	Dizziness, syncope, blurred vision and somnolence reported	Do not drive after dosing

Before-Use Safety Checklist

Side Effects

Dapoxetine adverse reactions, from the approved product information: 

Side Effect	Frequency	What To Do
Dizziness	Very common (>1 in 10)	Sit or lie down; do not drive
Headache	Very common	Usually mild
Nausea	Very common	Take after a light meal
Anxiety or agitation	Common (1 in 100 to 1 in 10)	Tell your doctor promptly
Insomnia or abnormal dreams	Common	Report if it disrupts sleep
Somnolence	Common	Do not drive
Tremor or paraesthesia	Common	Report to your doctor
Blurred vision	Common	Do not drive
Tinnitus	Common	Report to your doctor
Erectile dysfunction	Common	Discuss at your review
Decreased libido	Common	Discuss at your review
Increased blood pressure	Common	Have it checked
Hyperhidrosis (sweating)	Common	Usually settles
Gastrointestinal disorders	Common	Report if persistent
Syncope with loss of consciousness	0.23% at 60 mg	Emergency; see section 8
Orthostatic hypotension	Reported in trials	Stop use; seek advice

Sildenafil adverse reactions, from the approved product information: 

Side Effect	Frequency	What To Do
Headache	Very common	Rest and hydrate
Flushing	Common	Settles as the drug wears off
Dyspepsia	Common	Avoid heavy meals
Nasal congestion	Common	Temporary
Visual colour distortion or blurred vision	Common	Avoid driving
Priapism	Rare	Emergency; see section 8
NAION (sudden vision loss)	Rare	Emergency; stop permanently
Sudden hearing loss	Rare	Emergency; stop immediately
Heart attack, stroke, arrhythmia	Rare	Emergency; call for help
Stevens-Johnson syndrome	Rare	Emergency; stop immediately

Expect both sets. Dizziness, headache, and nausea appear on both lists and are very common with dapoxetine alone. 

Drug Interactions – Avoid With

Contraindicated with dapoxetine: 

Contraindicated with sildenafil: 

Dose-restricting or caution: 

Also avoid:

Always show your doctor a full list of your medicines.

Emergency Warning Signs

Stop the medicine and seek immediate medical care if you experience:

Signs of serotonin syndrome a medical emergency: 

Mental health emergency:

Contact a doctor or emergency service straight away. If you are in crisis, contact your local emergency number or a crisis helpline.

Tell emergency staff what you have taken. Name both sildenafil and dapoxetine, and bring the pack so they can read the strengths. They must not give you nitrate medicines.

What to Know Before Choosing This Product

This section reports the evidence rather than making a recommendation.

What the two molecules offer at approved doses:

What this product does not offer:

What is known about the combination:

Standard practice for men with both conditions:

Storage Instructions

Medical Disclaimer

This content is for information only. It is not medical advice. Extra Super Enjofil is a prescription-only medicine containing two active ingredients. Published sources do not agree on its strengths; read the pack before use and do not take it if both strengths are not clearly stated. Dapoxetine is approved at 30 mg and 60 mg only, with 30 mg the recommended starting dose and 60 mg the maximum. The dapoxetine product information states that it should not be used in men taking phosphodiesterase type 5 inhibitors such as sildenafil, as this increases the risk of syncope. Alcohol should be avoided entirely. Nitrate medicines are contraindicated with sildenafil. Use only under a qualified doctor’s supervision, with an orthostatic assessment before starting and review after 4 weeks. Always read the manufacturer’s package insert supplied with your product before use.

Mental health topics are covered on this page because they are directly relevant to dapoxetine. If you are struggling with your mental health, speak to a doctor or a trusted person. Support is available.