What is Super Enjofil 160 mg?

What each ingredient does

Why this combination has a better footing than most

What this tablet does not do

How It Works (Mechanism of Action)

Sildenafil, on the erection side

Dapoxetine, on the ejaculation side

Where the two meet, and why the European label objects

Why sildenafil causes vision changes at this dose

Timing and clearance

Property	Sildenafil 100 mg	Dapoxetine 60 mg
Peak level	30 to 120 minutes, median 60	About 1 to 2 hours
Dosing window	30 minutes to 4 hours before	1 to 3 hours before
Bioavailability	About 41 percent	About 42 percent
Half-life	About 4 hours	Initial 1.5 hours; terminal about 19
Protein binding	About 96 percent	Over 99 percent
Cleared by	CYP3A4 mainly, CYP2C9 minor	CYP2D6, CYP3A4 and FMO1
Effect of food	Fatty meal delays peak 60 min, cuts it 29 percent	No clinically significant effect

Dosage Guide

Unusually for this category, an approved dose ladder exists. Here it is.

Situation	Sildenafil	Dapoxetine	Which approved combination fits?
Man new to both drugs	50 mg	30 mg	The 50 plus 30 product, not this one
Tolerating 30 mg dapoxetine, 50 mg enough	50 mg	60 mg	The 50 plus 60 product
Established on both at these doses	100 mg	60 mg	Super Enjofil 160. This is the fit.
Had faintness on dapoxetine 30 mg	Doctor decides	Do not increase	None. Dapoxetine becomes contraindicated.
Aged 65 or over	Start at 25 mg	Not established	None. Dapoxetine unproven in this group.
Liver impairment, any degree	Start at 25 mg	Contraindicated at Child-Pugh B or C	None.
Severe kidney impairment	Start at 25 mg	Not recommended	None.
On an alpha-blocker	Start at 25 mg	Caution	None. Four times the sildenafil start.
On erythromycin or a strong antifungal	Start at 25 mg	Contraindicated for several	None.
On ritonavir	25 mg per 48 hours	Contraindicated	None.
Women, children, under-18s	Not indicated	Not indicated	None.

How to Take It

The fatty meal point, which matters for sildenafil

The first three hours

If you feel faint

Missed doses

Precautions

Absolute contraindications

From the sildenafil component:

From the dapoxetine component:

Tell your doctor about

Food, drink and other substances

Before-use checklist

Side Effects

Sildenafil, by dose

The 100 mg column applies to this tablet.

Effect	Placebo	25 mg	50 mg	100 mg
Headache	7%	16%	21%	28%
Flushing	2%	10%	19%	18%
Indigestion	2%	3%	9%	17%
Abnormal vision	1%	1%	2%	11%
Nasal congestion	2%	4%	4%	9%
Back pain	2%	3%	4%	4%
Dizziness	2%	3%	4%	3%
Nausea	1%	2%	3%	3%

Dapoxetine, by dose

Effect	At 30 mg	At 60 mg
Nausea	11.0%	22.2%
Dizziness	5.8%	10.9%
Headache	5.6%	8.8%
Diarrhoea	3.5%	6.9%
Fatigue	2.0%	4.1%
Insomnia	2.1%	3.9%

Uncommon and rare effects

Where	What has been reported
Fainting and pressure	Fainting, vasovagal fainting, low pressure, dizziness on standing
Heart and vessels	Angina, palpitations, fast heartbeat, sinus arrest, chest pain
Heart, rare and serious	Heart attack, sudden cardiac death, ventricular arrhythmia, stroke
Eyes	Double vision, temporary vision loss, red eyes, burning, light sensitivity
Eyes, rare and serious	NAION, retinal bleeding, raised eye pressure, vitreous detachment
Ears	Tinnitus, ear pain, sudden decrease or loss of hearing
Mood	Anxiety, agitation, abnormal dreams, depression, confusion, reduced libido
Nerves	Tremor, vertigo, numbness, insomnia, drowsiness, seizure, transient amnesia
Digestive	Vomiting, dry mouth, gastritis, reflux, constipation, abnormal liver tests
Breathing	Nosebleed, breathlessness, sinusitis, cough, sore throat
Sexual	Erectile dysfunction, ejaculation failure, orgasm difficulty
Genital and urinary	Prolonged erection, priapism, blood in urine, abnormal ejaculation
Skin	Hives, itching, sweating, cold sweat, contact dermatitis
Blood, rare	Vaso-occlusive crisis reported in sickle cell disease with a related product

Drug Interactions – Avoid With

Severity	Substance	Consequence
ABSOLUTE BAN	Nitrates in any form, including sprays and patches	Blood pressure can fall to a fatal level
ABSOLUTE BAN	Poppers: amyl nitrite, butyl nitrite	Identical danger
ABSOLUTE BAN	Riociguat and guanylate cyclase stimulators	Unsafe blood pressure fall
ABSOLUTE BAN	MAOI antidepressants, and 14 days after stopping	Risk of fatal serotonin reactions
ABSOLUTE BAN	Other SSRIs, SNRIs and tricyclics	Serotonin syndrome
ABSOLUTE BAN	Lithium, tramadol, triptans, linezolid, L-tryptophan	Serotonin syndrome
ABSOLUTE BAN	St John’s Wort and serotonergic herbals	Serotonin syndrome
ABSOLUTE BAN	Thioridazine, and 14 days after stopping	Dangerous rhythm disturbance
ABSOLUTE BAN	Ketoconazole, itraconazole, ritonavir, saquinavir, atazanavir	Dapoxetine exposure roughly doubles
ABSOLUTE BAN	Another PDE-5 inhibitor or dapoxetine product	Silent doubling of one or both components
ABSOLUTE BAN	Recreational drugs: MDMA, LSD, ketamine	Serotonin syndrome, arrhythmia, high fever
DOSE PROBLEM	Erythromycin, clarithromycin	Sildenafil exposure up 182%; dapoxetine capped at 30 mg
DOSE PROBLEM	Fluconazole, verapamil, diltiazem	Dapoxetine must be capped at 30 mg
CAUTION	Cimetidine	Sildenafil levels rise about 56 percent
CAUTION	Alpha-blockers: doxazosin, tamsulosin, alfuzosin, silodosin	Dizziness, fainting, low pressure on standing
CAUTION	Amlodipine and other blood pressure medicines	Extra fall of about 8/7 mmHg
CAUTION	Warfarin, aspirin, NSAIDs, antiplatelets	SSRIs can affect platelets and bleeding
CAUTION	Sedatives, opioids, benzodiazepines	Added drowsiness and dizziness
AVOID	Alcohol	Drowsiness, poor judgement, fainting, injury
AVOID	Grapefruit juice within 24 hours	Raises both drug levels
WEAKENS IT	Bosentan, rifampicin	Sildenafil exposure falls substantially

Emergency Warning Signs

Stop and get urgent medical help if any of these occur:

Why Choose Super Enjofil 160 mg

What holds up

What does not hold up

Storage Instructions

Medical Disclaimer