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Nitroglycerin Ointment 30g
| Active Ingredient | Nitroglycerin/Glyceryl Trinitrate |
|---|---|
| Indication | Anal fissure |
| Manufacturer | Actiza Pharmaceutical Pvt. Ltd. |
| Strength:- | 30g |
| Packaging | 30 gm in 1 tube |
| Dosage Form:- | Cream |
| Country of Origin | India |
Nitroglycerin Ointment 30g |
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|---|---|---|---|---|
| Pack Size | Price | Quantity | Add To Cart | |
| 1 Cream/s | $10 | |||
| 3 Cream/s | $28 | |||
| 6 Cream/s | $52 | |||
| 12 Cream/s | $99 | |||
Critical Safety Warnings
What is Nitroglycerin Ointment 30g?
Nitroglycerin ointment (30g tube) is a topical medicine available in the market, useful for the treatment of chronic anal fissures and for the prevention of angina (chest pain). It primarily belongs to the class of drugs called nitrates, which relax blood vessels and improve blood flow in the targeted areas.
What is Chronic Anal Fissure?
A chronic anal fissure is a small tear (in the lining of the anus) that fails to heal even after a few weeks.
It can cause severe pain, there can be bleeding during bowel movements, and muscle spasms. Reduced blood flow to the area can often delay healing, necessitating treatment.
How Does Nitroglycerin Ointment Work?
Nitroglycerin works by releasing nitric oxide, which helps relax smooth muscles and widens blood vessels, thereby improving blood circulation and reducing pressure.
Mechanism of Action
Step-by-Step Mechanism (Anal Fissure Use):
Mechanism for Angina Prevention:
Dosage & Application Instructions
Individuals must follow the doctor’s advice and take the prescribed dosage, based on the patient’s health.
Step-by-Step Application – Anal Fissure Use
Step-by-Step Application – Angina Prevention
Nitrate Tolerance – Critical for Angina Use
Continuous use can reduce effectiveness over time; therefore, doctors may recommend a nitrate-free interval to maintain full effectiveness.
Special Population Notes:
Elderly patients at the time of use have to be extra careful, as they may be more sensitive to blood pressure changes.
Caution has to be taken in women who are pregnant or breastfeeding.
Should not be given to children unless prescribed by a specialist.
Safety Information
It is advisable to avoid sudden movement right after applying the ointment, as dizziness may occur.
Do not try to take a higher dose than recommended.
Must inform your doctor if you have been suffering from any pre-existing conditions like heart conditions, low blood pressure, or medications you are taking.
Side Effects
Additional Adverse Effects from General Nitroglycerin Use
Managing Headaches – Most Important Patient Concern
Headaches are a common side effect of blood vessel dilation, but they do improve over time.
It is advisable to stay hydrated, take proper rest, and even use mild pain relievers to help manage them.
Contraindications
Absolute Contraindications – NEVER use Nitroglycerin Ointment if:
Use With Caution – Medical Assessment Required:
Drug Interactions
Nitroglycerin is seen to interact with certain medicines and these are erectile dysfunction medicines, blood pressure drugs, consuming alcohol as it increases dizziness, and certain antidepressants.
Overdose Information
Overuse can lead to some serious conditions like severe hypotension, fainting, confusion, and even shock. Some symptoms might include an intense headache, blurred vision, and a rapid heartbeat. There is a need to seek immediate medical attention in case of suspected overdose.
Storage & Handling
The storage is suitable, and the medicine performs well when kept at room temperature, away from direct sunlight and heat.
Conclusion
Nitroglycerin ointment 30g is considered one of the safest and most effective treatments for chronic anal fissures and angina, when used appropriately. It offers a significant improvement in blood flow and reduces pressure. But it must be used very carefully, as there can be some side effects (when necessary precautionary measures are not taken). Hence, before using Nitroglycerin, it is advisable to consult with a doctor beforehand.
FAQ
Q1:- How do you apply nitroglycerin ointment for anal fissure?
Ans:- Cover your finger with plastic wrap or a glove. Squeeze 1 inch of ointment from the tube onto your covered finger using the dosing line on the carton (375mg ointment = 1.5mg nitroglycerin). Gently insert the covered finger into the anal canal no further than the first knuckle and smear the ointment around the inside. Apply every 12 hours.
Q2:-Does nitroglycerin ointment cause headaches?
Ans:- Yes, headache is the most common side effect, affecting 57.3% of patients in clinical trials. This is an expected pharmacological effect of nitroglycerin’s vasodilating action, not an allergic reaction. Headaches typically become less severe after the first few days of use. Paracetamol (acetaminophen) effectively manages this side effect.
Q3:- How long does nitroglycerin ointment take to work for anal fissure?
Ans:- Pain relief typically begins within 20-30 minutes of applying nitroglycerin ointment. Clinical improvement in fissure pain is usually noticeable within the first 1-2 weeks. The full treatment course is up to 3 weeks. If pain persists after 3 weeks, consult your doctor, other treatments or further assessment may be needed.
Q4:- What is nitrate tolerance and how do I prevent it?
Ans:- Nitrate tolerance is when nitroglycerin becomes less effective over time because the body adapts to the drug. It develops within 24-48 hours of continuous use. To prevent tolerance when using nitroglycerin for angina, a daily nitrate-free interval of 10-12 hours is essential typically overnight. For anal fissure (up to 3 weeks), tolerance is less clinically relevant.
Q5:- Can nitroglycerin ointment heal an anal fissure permanently?
Ans:- Nitroglycerin ointment relieves pain and promotes healing, but healing rates vary. In clinical studies, approximately 49-68% of patients experience fissure healing. However, recurrence rates after stopping treatment are approximately 50%. If conservative treatment and nitroglycerin fail, botulinum toxin injection or lateral internal sphincterotomy (surgery) are the next steps.
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