Super Tastylia 80 Mg (Tadalafil/Depoxetine)

What is Super Tastylia 80 mg?

What each ingredient does

Important limits

Regulatory status, stated for accuracy

How It Works (Mechanism of Action)

Tadalafil: the erection pathway

Dapoxetine: the ejaculation pathway

Why the two are combined, and why that needs care

Absorption and clearance

Property	Tadalafil	Dapoxetine
Time to peak level	30 minutes to 6 hours (median 2 hours)	About 1 to 2 hours
Bioavailability	Not determined	About 42 percent
Protein binding	About 94 percent	Over 99 percent
Half-life	About 17.5 hours	Initial 1.5 hours; terminal about 19 hours
Main liver enzymes	CYP3A4	CYP2D6, CYP3A4 and FMO1
Effect of food	No effect	No clinically significant effect
Main route out	Faeces about 61%, urine about 36%	Urine, as conjugated metabolites

Dosage Guide

A doctor must set the dose. This table shows approved dosing for each component.

Patient group or situation	Tadalafil	Dapoxetine	Frequency	Key note
Adult men 18-64, new to dapoxetine	10 mg start	30 mg start	Once in 24 hours	This fixed product does not fit here
Adult men 18-64, tolerating 30 mg dapoxetine	10–20 mg	60 mg	Once in 24 hours	This is the group this product suits
Had faintness on 30 mg dapoxetine	Doctor decides	Do not increase	Not applicable	No step-up to 60 mg is allowed
Men aged 65 and over	No change for age	Not established	Not applicable	Dapoxetine is unproven in this age group
Liver: mild impairment	Max 10 mg	Caution	Once in 24 hours	Specialist judgement needed
Liver: moderate or severe	Caution or avoid	Contraindicated	Do not use	Dapoxetine is banned in Child-Pugh B and C
Kidney: mild or moderate	May need adjusting	Caution	Once in 24 hours	A fixed tablet cannot be adjusted
Kidney: severe	Max 5 mg per 72 hours	Not recommended	Do not use	Neither component fits this group
On moderate CYP3A4 inhibitors	Caution	Max 30 mg	Once in 24 hours	60 mg exceeds the allowed dapoxetine dose
On potent CYP3A4 inhibitors	Max 10 mg per 72 hours	Contraindicated	Do not use	See the interaction table in Section 7
Women, children, under-18s	Not indicated	Not indicated	Not applicable	Not for use in these groups

How to Take It

Step-by-step:

The first three hours matter most

If you feel faint

Missed doses

Precautions

Absolute contraindications (never use)

This product inherits the contraindications of both drugs. The combined list is long.

From the tadalafil component:

From the dapoxetine component:

Conditions to disclose to your doctor

Food and drink precautions

Before-use safety checklist

Side Effects

Common side effects, by ingredient

Dapoxetine rates are from phase 3 trials. Tadalafil rates are from as-needed trials.

Side effect	Source drug	At lower dose	At this product’s dose
Nausea	Dapoxetine	11.0% at 30 mg	22.2% at 60 mg
Dizziness	Dapoxetine	5.8% at 30 mg	10.9% at 60 mg
Headache	Dapoxetine	5.6% at 30 mg	8.8% at 60 mg
Diarrhoea	Dapoxetine	3.5% at 30 mg	6.9% at 60 mg
Fatigue	Dapoxetine	2.0% at 30 mg	4.1% at 60 mg
Insomnia	Dapoxetine	2.1% at 30 mg	3.9% at 60 mg
Headache	Tadalafil	11% at 10 mg	15% at 20 mg
Indigestion	Tadalafil	8% at 10 mg	10% at 20 mg
Back pain	Tadalafil	5% at 10 mg	6% at 20 mg
Muscle pain	Tadalafil	4% at 10 mg	3% at 20 mg
Blocked nose	Tadalafil	3% at 10 mg	3% at 20 mg
Flushing	Tadalafil	3% at 10 mg	3% at 20 mg

Less common and rare side effects

Body system	Reported effects
Fainting and blood pressure	Fainting, vasovagal fainting, low blood pressure, dizziness on standing
Heart rhythm	Sinus arrest, slow heartbeat, fast heartbeat, palpitations
Serious cardiovascular (rare)	Heart attack, sudden cardiac death, stroke
Mood and mental state	Anxiety, agitation, restlessness, abnormal dreams, reduced libido
Mood (uncommon)	Depression, depressed mood, nervousness, confusion, apathy, nightmares
Nervous system	Drowsiness, poor concentration, tremor, tingling, tooth grinding
Eyes	Blurred vision, dilated pupils, eye pain, visual disturbance
Eyes (rare, serious)	NAION, retinal vein or artery occlusion, visual field defect
Ears	Ringing in the ears, vertigo, sudden decrease or loss of hearing
Digestive	Vomiting, constipation, abdominal pain, wind, dry mouth, reflux
Sexual	Erectile dysfunction, ejaculation failure, orgasm difficulty, loss of libido
Urinary and genital	Prolonged erection, priapism
Skin	Sweating, cold sweat, itching, rash, hot flushes
Skin (rare, serious)	Stevens-Johnson syndrome, exfoliative dermatitis
General	Feeling hot, feeling jittery, weakness, feeling drunk

Drug Interactions – Avoid With

Risk level	Drug or substance	What happens
NEVER COMBINE	All organic nitrates and nitrite poppers	Severe, possibly fatal blood pressure drop
NEVER COMBINE	Riociguat and other guanylate cyclase stimulators	Blood pressure may fall to an unsafe level
NEVER COMBINE	MAOI antidepressants, and for 14 days after stopping	Risk of fatal serotonin reactions
NEVER COMBINE	Other SSRIs, SNRIs and tricyclic antidepressants	Serotonin syndrome
NEVER COMBINE	Lithium, tramadol, triptans, linezolid, L-tryptophan	Serotonin syndrome
NEVER COMBINE	St John’s Wort and serotonergic herbal products	Serotonin syndrome
NEVER COMBINE	Thioridazine, and for 14 days after stopping	Dangerous heart rhythm disturbance
NEVER COMBINE	Ketoconazole, itraconazole, ritonavir, saquinavir	Dapoxetine exposure roughly doubles
NEVER COMBINE	Telithromycin, nefazodone, nelfinavir, atazanavir	Dapoxetine exposure roughly doubles
NEVER COMBINE	Other PDE-5 inhibitors, or other tadalafil products	Accidental double dosing
NEVER COMBINE	Recreational drugs: MDMA, LSD, ketamine	Serotonin syndrome, arrhythmia, high fever
DOSE PROBLEM	Moderate CYP3A4 inhibitors: erythromycin, clarithromycin	Dapoxetine must be capped at 30 mg
DOSE PROBLEM	Fluconazole, verapamil, diltiazem, aprepitant	Dapoxetine must be capped at 30 mg
USE WITH CAUTION	Potent CYP2D6 inhibitors such as fluoxetine	Dapoxetine active fraction may double
USE WITH CAUTION	Alpha-blockers: doxazosin, tamsulosin, alfuzosin	Reduced tolerance to standing; fainting risk
USE WITH CAUTION	Blood pressure medicines and angiotensin II blockers	Additional blood pressure fall
USE WITH CAUTION	Warfarin, aspirin, NSAIDs, antiplatelet drugs	SSRIs can affect platelets and bleeding
USE WITH CAUTION	Sedatives, opioids, benzodiazepines, antiepileptics	Added drowsiness and dizziness
AVOID	Alcohol	Drowsiness, poor judgement, fainting, injury
AVOID	Grapefruit juice, within 24 hours before the dose	Potent CYP3A4 inhibition raises drug levels
REDUCED EFFECT	Rifampicin, carbamazepine, phenytoin, phenobarbital	Tadalafil exposure falls sharply

Emergency Warning Signs

Stop the medicine and get emergency medical care if any of these occur:

Why Choose This Combination

Storage Instructions

Medical Disclaimer