Sevista 60 Mg (Ormeloxifene/Centchroman) Medically reviewed by Sanjay Gangani, B.Pharm, CMO & Pharmacist
Active Ingredient Ormeloxifene/centchroman Indication Contraception Manufacturer Torrent Pharmaceuticals Ltd. Strength:- 60mg Packaging 15 tablets in 1 strip Dosage Form:- Tablet Country of Origin India
INQUIRE ABOUT Sevista 60 Mg (Ormeloxifene/Centchroman)
What is Sevista 60 mg? Sevista is a prescription tablet containing 60 mg of ormeloxifene.
Ormeloxifene is also known by its older name, centchroman.
It is a selective oestrogen receptor modulator, or SERM.
It is non-hormonal and non-steroidal.
It was discovered at the Central Drug Research Institute in Lucknow.
It is manufactured under this brand by Torrent Pharmaceuticals.
Torrent markets Sevista to treat dysfunctional uterine bleeding.
That means heavy or irregular periods with no structural cause.
The same molecule is also used as a weekly contraceptive.
For contraception, the standard strength is Sevista 30 mg , not 60 mg.
It is not raloxifene, an osteoporosis drug with a similar name.
It is approved essentially only in India.
It does not protect against sexually transmitted infections.
Use Sevista only for the purpose your doctor prescribed.
How Sevista Works (Mechanism of Action) The action happens in five simple steps:
Oestrogen stimulates the lining of the womb to thicken.
An overly thick lining can bleed heavily or irregularly.
Ormeloxifene blocks oestrogen action in the womb lining.
The lining therefore builds up less than before.
Bleeding becomes lighter and more regular over time.
A study treated women with 60 mg twice weekly for three months.
It then continued at once weekly for a further three months.
Haemoglobin rose significantly over the treatment period.
Womb lining thickness fell significantly over the same period.
Other causes of bleeding had been ruled out beforehand.
Ormeloxifene stays in the body for a long time.
That allows twice-weekly and then weekly dosing.
The weekly schedule is simpler than a daily tablet.
Dosage Guide Your doctor sets the schedule. It is not a daily tablet.
Situation Published Regimen Timing Key Note Uterine bleeding, first phase 60 mg twice weekly For three months As used in a published study Uterine bleeding, second phase 60 mg once weekly For a further three months As used in the same study Choosing the two weekly days Keep them evenly spaced The same days each week For example Sunday and Wednesday Contraception 30 mg, not this strength Twice weekly for 12 weeks, then weekly A different product Using Sevista for contraception Seek medical advice first Not applicable It is twice the contraceptive dose Before treating bleeding Other causes must be excluded Before starting Including pregnancy and cancer Pregnancy Do not use Not applicable Confirm you are not pregnant Missed dose Take it as soon as you remember Keep the schedule Ask your doctor if unsure
How to read this table:
Your doctor’s written schedule is the authority, not this page.
The bleeding regimen shown comes from a published clinical study.
Your doctor may use a different duration.
Never take it daily unless specifically told to.
Do not assume 60 mg gives better contraception than 30 mg.
How to Take Sevista Confirm the purpose of your prescription with your doctor.
Make sure other causes of your bleeding have been checked.
Choose two evenly spaced days each week for the first phase.
Swallow the tablet whole with water on those days.
Mark the days on a calendar or phone reminder.
Continue twice weekly for as long as your doctor directs.
Then move to once weekly on a fixed day.
Keep a record of your bleeding pattern.
Attend any follow-up blood test or scan arranged.
A weekly schedule is easy to forget, so set a reminder.
Expect your periods to change, including a possible delay.
Take a pregnancy test if a period is very late.
Do not rely on this tablet for contraception without advice.
Report bleeding that becomes heavier or more frequent.
Precautions Do Not Use Sevista If You: Are pregnant or might be pregnant.
Are allergic to ormeloxifene or any tablet ingredient.
Have abnormal bleeding whose cause has not been investigated.
No regulatory label was available to verify a complete list.
The pack insert supplied with the tablets is the authority.
Conditions You Must Disclose to Your Doctor Any liver disease or recent jaundice.
Any kidney disease.
Polycystic ovary syndrome.
Any known growth or abnormality of the cervix or womb.
Any history of breast disease.
Any chronic illness or long-term infection.
Whether you are breastfeeding.
Any hormonal contraception or hormone treatment you use.
All prescription, herbal and over-the-counter products you use.
Food, Drink and Lifestyle The tablet can be taken with or without food.
No specific food needs to be avoided.
Iron-rich foods may help if heavy bleeding caused anaemia.
Your doctor may also prescribe iron supplements.
Limit alcohol, which can affect bleeding and the liver.
Before-Use Checklist Do you hold a valid prescription for Sevista 60 mg?
Is it prescribed for bleeding rather than contraception?
Have other causes of your bleeding been investigated?
Have you confirmed you are not pregnant?
Do you understand it is taken weekly, not daily?
Do you know which days you will take it?
Have you disclosed any liver or kidney disease?
Do you know your periods may be delayed?
Have you read the pack insert’s contraindications?
Have you checked the expiry date on the strip?
Common and Less Common Side Effects A change in menstrual timing is the effect most people notice.
Side Effect Frequency What It Feels Like What to Do Delayed period Common Period arriving later than usual Take a pregnancy test if very late Prolonged cycle Common Longer gap between periods Usually expected; report if troubling Nausea Common Queasy stomach Take with food Headache Common Dull or throbbing head pain Rest and drink water Dizziness Less common Light-headed feeling Sit down until it passes Weight gain Less common Gradual weight increase Report if significant Stomach upset Less common Mild digestive discomfort Report if persistent Heavier bleeding Uncommon Bleeding increasing rather than easing Contact your doctor Severe allergic reaction Rare Swelling of face, lips or throat Emergency — call for help
About delayed periods:
Delayed menstruation is the characteristic effect of ormeloxifene.
It is expected and usually not a cause for concern.
A very late period should still prompt a pregnancy test.
Tell your doctor if cycles become very long or stop.
Drug Interactions – Use With Caution Tell your doctor before combining Sevista with:
Hormonal contraceptives or hormone replacement therapy.
Other medicines for heavy menstrual bleeding.
Other oestrogen receptor modulators such as tamoxifen.
Another ormeloxifene product, including a contraceptive one.
Blood thinners, which can worsen bleeding.
Herbal products marketed for periods or hormones.
Two ormeloxifene products together would stack the dose.
Hormone treatments may work against its effect on the womb.
Blood thinners can increase menstrual bleeding.
Herbal products may contain undeclared hormonal ingredients.
Emergency Warning Signs – Seek Urgent Medical Help Seek same-day medical advice if you have:
Bleeding that soaks a pad or tampon every hour.
Bleeding with dizziness, fainting or breathlessness.
A positive pregnancy test while taking it.
Severe pain in the lower abdomen.
Yellowing of the skin or eyes.
Bleeding after the menopause at any time.
Very heavy bleeding with collapse.
Swelling of the face, lips, tongue or throat.
Difficulty breathing.
Tell every treating doctor that you take ormeloxifene.
State the strength and why it was prescribed.
Bring the pack with you if that is possible.
Why Choose Sevista 60 mg? Benefits when clinically appropriate:
It is non-hormonal, avoiding the effects of hormonal treatments.
It is taken weekly rather than every day.
A published study showed reduced womb lining thickness.
The same study showed improved haemoglobin levels.
It was discovered and developed in India.
Torrent Pharmaceuticals is a large, established manufacturer.
It is an oral alternative to more invasive bleeding treatments.
It is approved essentially only in India.
Other causes of bleeding must be ruled out before using it.
It commonly delays menstrual periods.
This strength is not the standard contraceptive dose.
The evidence base is smaller than for widely approved alternatives.
A regulatory label was not available to verify every detail.
Heavy bleeding can have serious causes needing investigation.
Storage Instructions Store at room temperature in a cool, dry place.
Keep tablets in the original strip until use.
Protect from direct sunlight, heat and moisture.
Do not store in the bathroom or near a sink.
Keep the pack out of sight and reach of children.
Keep away from pets at all times.
Check the expiry date printed on the strip.
Do not use tablets that are chipped, damp or discoloured.
Keep Sevista separate from any 30 mg contraceptive tablets.
Never share this medicine with another person.
Return unused tablets to a pharmacy take-back scheme.
Sanjay Gangani
B.Pharm, CMO & Pharmacist
Licensed pharmacist (B.Pharm) with 12+ years in clinical pharmacy and patient care. Reviews every article for evidence-based accuracy before it is published on ACTIZA Store.
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