Premarin Vaginal Cream

Premarin Vaginal Cream (Conjugated Estrogen)

Active Ingredient Conjugated Estrogen
Indication Contraception, Post menopausal osteoporosis, Hormone replacement therapy
Manufacturer Pfizer India Ltd
Packaging 14 gm in 1 tube



Premarin Vaginal Cream is a widely used medication that is primarily used to treat symptoms of menopause in women. This is specifically for those related to vaginal atrophy.

The cream contains conjugated estrogen which is mainly a mixture of estrogen hormones derived from natural sources. These particular hormone helps to reduce the symptoms within women leading to postmenopausal.

Uses of Premarin Vaginal Cream

Premarin Vaginal Cream is associated with the control of various conditions associated with the estrogen deficiency.

  • Treatment of vaginal atrophy

The condition is often experienced before or after the menopause. Mainly the condition involves, drying, thinning and also inflammation. This mainly happens due to the decreased level in the estrogen level.

In turn, the side-effects result in itching, a burning sensation and dryness in the vagina.

  • Associated urine symptoms (of Vaginal atrophy)

Premarin Vaginal Cream is also found to be effective in treating or managing the urinary symptoms. This mainly involves painful urination, urine urgency and also frequency.

All of these symptoms last due to the estrogen deficiency and upon applying the Premarin Vaginal Cream, all of these signs can be easily alleviated.

  • Part of hormone replacement therapy

The use of Cream is also seen within the hormone replacement therapy. It can be combined with systemic hormone therapies to easily address the wide range of menopausal symptoms.

  • Prevention towards Osteoporosis

Estrogen therapy can also have a positive impact on bone health. This is done upon maintaining the estrogen level, and it may indirectly help Osteoporosis.

Benefits of Premarin Vaginal Cream

Numerous benefits have been reported upon using Premarin Vaginal Cream.

The cream helps to restore the vaginal lubrication, tends to reduce discomfort and also dryness.

This manner, Premarin cream helps to reduce the burning and also irritation developed within the vagina.

Tends to improve lubrication, also tissue health that results in painful sexual intercourse. This results in enhanced sexual intimacy.

The localized estrogen therapy helps to promote the elasticity and even the thickness of the vaginal walls.

The main benefit of using this cream is seen towards restoring the natural lubricant which in turn prevents discomfort.

How to use Premarin Vaginal Cream

Before using Premarin vaginal cream, it is necessary to read out all of the instructions carefully.

  • You must not extend the dose beyond what you have been recommended too.
  • Wash your hands with soap thoroughly before using the Premarin vaginal cream.
  • Make sure before using cream, the applicator is clean.
  • Now remove the cap from the this cream and screw the applicator onto the tube.
  • Squeeze the desired amount to the applicator and choose the comfortable position for applying.
  • Once you have filled the applicator now you have to slowly insert it into vagina and discharge the cream.

What to do if I have skipped applying Premarin Vaginal Cream?

If you remember to apply the cream then you can ensure to apply the cream. But if it is the time for your next dose (that is you are near to your next dose) then you can skip the first and jump to the next one).

Side Effect

  • Headache
  • Nausea
  • Abnormal bleeding
  • Fever
  • Fatigue
  • Weight gain
  • Hair fall
  • Acne
  • Itching
  • Breast pain
  • Breast tenderness
  • Feeling low
  • Insomnia
  • Nervousness

Precautions and Warnings

  • Alcohol

When taking Premarin Vaginal Cream with alcohol, you should be careful. Talk to your doctor, please.

  • Pregnancy

It is very dangerous to use Premarin Vaginal Cream while you are pregnant. Talk to your doctor because studies on pregnant women and animals have shown that this can have very bad effects on the growing baby.

  • Breast feeding

It is safe to take this Cream while nursing. Researchers who have tested the drug on humans have found that it does not enter breast milk in large amounts and does not harm the baby.

  • Driving

Premarin Vaginal Cream might make you less alert, blur your vision, or make you sleepy and dizzy. If these things happen, do not drive.

  • Kidney

There isn’t a lot of information about how to use Premarin Cream in people who have kidney disease. Talk to your doctor, please.

  • Liver

Premarin Vaginal Cream is probably not safe for people with liver disease to take, so they should stay away from it. Talk to your doctor, please.

Storage and disposal

  • Store it below 25°C in a cool and dry place.
  • Keep it away from children and pets.
Chemical ClassEstradiol Congeners
Habit Forming
Therapeutic Class

Alternative Medicines

Yaz Tablet | Yasmin | Cerazette Tablet 


Q.1 What is Premarin Vaginal Cream and what it is used for?

Premarin Vaginal Cream is an estrogen cream used to treat symptoms of vaginal dryness, irritation, and painful intercourse associated with menopause.

Q.2 How to use Premarin Vaginal Cream?

This Cream is typically applied directly into the vagina using the provided applicator, as directed by your healthcare provider, usually once daily for a certain period.

Q.3 What if I forget to use Premarin Vaginal Cream?

You should use Cream as soon as you remember if you forget to. If it’s almost time for your next dose, though, don’t take the one you missed. Instead, go back to your normal dosing schedule.

Q.4 What are the common side effects of using Premarin Vaginal Cream?

Common side effects of Cream may include vaginal irritation, itching, discharge, or discomfort.


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