Hucog 5000 HP Injection (HCG)

What is Hucog 5000 HP Injection

Product identity

Field	Detail
Brand name	Hucog 5000 HP Injection
Generic name	Chorionic Gonadotrophin (human chorionic gonadotropin, hCG)
Strength	5000 IU per ml
Pack	1 ml vial
Drug class	Gonadotrophin; luteinising hormone (LH) analogue
Marketing company	Bharat Serums and Vaccines Ltd, Mumbai
Manufacturing site listed	Kabilpore, Navsari, Gujarat, India
Primary uses	Ovulation trigger; male hypogonadotropic hypogonadism; cryptorchidism
Route	Intramuscular or subcutaneous, as prescribed
MRP (listed)	About Rs. 445.95 per 1 ml vial
Storage	Refrigerate at 2 to 8 degrees Celsius; do not freeze
Legal status in India	Prescription only, Schedule H
ATC code	G03GA01 (chorionic gonadotrophin)

How it works (mechanism of action)

The core principle

Why “highly purified” matters

Dosage guide

All figures below come from the reference label. Your specialist sets your dose.

Indication	Patient group	Regimen from the reference label	Role of a 5000 IU vial
Ovulation induction	Anovulatory infertile women	5,000 to 10,000 USP Units as one dose	One vial gives the lowest labelled dose
Ovulation induction – timing	Anovulatory infertile women	Given one day after the last menotropins dose	Timing is set by the clinic
Hypogonadotropic hypogonadism	Males, regimen A	500 to 1,000 Units three times weekly for three weeks	One vial covers several low doses
Hypogonadotropic hypogonadism	Males, regimen A continued	Then twice weekly for three weeks	Dose unchanged, frequency reduced
Hypogonadotropic hypogonadism	Males, regimen B	4,000 Units three times weekly for six to nine months	Close to one full vial per dose
Hypogonadotropic hypogonadism	Males, regimen B continued	Then 2,000 Units three times weekly for three months	About two doses per vial
Prepubertal cryptorchidism	Boys, usually aged 4 to 9	4,000 Units three times weekly for three weeks	Close to one vial per dose
Prepubertal cryptorchidism	Boys, alternative regimen	5,000 Units every other day for four injections	One vial per injection
Prepubertal cryptorchidism	Boys, alternative regimen	500 to 1,000 Units per dose, 15 doses over six weeks	One vial covers several doses
Prepubertal cryptorchidism	Boys, alternative regimen	500 Units three times weekly for four to six weeks	One vial covers many doses

USP Units and IU – what the unit words mean

What is not established

Group	Position in the reference label
Kidney impairment	No specific dose adjustment is stated
Liver impairment	No specific dose adjustment is stated
Pregnancy	Not for use once pregnancy is established
Breastfeeding	Not an indication; discuss with the specialist
Primary ovarian failure	Explicitly outside the ovulation indication
Weight loss	Explicitly stated as not demonstrated effective

How to take it

Who gives the injection

Why the exact time is recorded in fertility cycles

Precautions

Absolute contraindications

Conditions to disclose to your doctor

Condition	Why it matters
Polycystic ovary syndrome	Higher risk of ovarian hyperstimulation
Many follicles seen on scan	Trigger may be cancelled or reduced
Previous hyperstimulation episode	Risk of recurrence is real
Any blood-clotting disorder	Arterial thromboembolism is reported
Previous clot in leg or lung	Needs specialist risk assessment
Heart disease	Androgens can cause fluid retention
Kidney disease	Androgens can cause fluid retention
Epilepsy	Named for caution in the reference label
Migraine	Named for caution in the reference label
Asthma	Named for caution in the reference label
Untreated thyroid or adrenal disorder	Must be corrected before treatment
Untreated pituitary tumour	Must be assessed before treatment
Undiagnosed vaginal bleeding	Needs investigation first
Ovarian, uterine or breast cancer	Needs specialist assessment
Any allergy to urine-derived products	Anaphylaxis has been reported

Food and drink precautions

Before-use safety checklist

Common and less common side effects

Group	Side effect	What to do
Common	Headache	Report if severe or persistent
Common	Pain, swelling or redness at the site	Usually settles in a day
Common	Tiredness or fatigue	Rest; report if marked
Common	Irritability or restlessness	Report to your clinic
Common	Low mood or depression	Report to your clinic
Common	Abdominal pain	Report; may signal hyperstimulation
Common	Abdominal bloating or distension	Report; may signal hyperstimulation
Common	Nausea	Report if it stops you drinking
Common	Vomiting	Report promptly
Less common	Fluid retention and swollen ankles	Report to your clinic
Less common	Breast tenderness	Usually settles after the cycle
Less common	Gynaecomastia in males	Report to your prescriber
Less common	Precocious puberty in treated boys	Stop therapy; see the doctor
Less common	Localised hypersensitivity rash	Report before the next dose
Serious	Ovarian hyperstimulation syndrome	Contact the clinic urgently
Serious	Ruptured ovarian cyst with internal bleeding	Emergency care at once
Serious	Arterial thromboembolism	Emergency care at once
Serious	Systemic allergic reaction or anaphylaxis	Emergency care at once
Serious	Pleural effusion with breathlessness	Emergency care at once
Outcome risk	Multiple pregnancy, mostly twins	Discussed before treatment

The multiple-pregnancy figure

Drug interactions – avoid with

Medicines and tests that matter

Drug, test or group	Interaction	Action
Menotrophin (hMG) injections	Used together; raises hyperstimulation risk	Specialist supervision only
FSH and urofollitropin	Used together in stimulation protocols	Specialist supervision only
GnRH agonists and antagonists	Alter the timing of the trigger	Clinic sets the schedule
Clomifene citrate	Often precedes the trigger	Only on a written protocol
Letrozole	Often precedes the trigger	Only on a written protocol
Testosterone preparations	Suppress the pituitary LH signal	Tell the prescriber before use
Anabolic steroids	Suppress natural gonadotrophins	Disclose any past or present use
Corticosteroids	May add to fluid retention	Tell the prescriber
Anticoagulants	Clot risk changes need review	Specialist review required
Home pregnancy tests	hCG itself causes a positive reading	Test only on the clinic date
Gonadotrophin blood assays	Interferes, especially with LH	Tell the laboratory
Any other hormone injection	Combined effects are hard to predict	Disclose everything you take

A sport and doping warning

Emergency warning signs

Go to hospital immediately

Warning sign	Possible cause
Rapidly swelling, painful abdomen	Ovarian hyperstimulation syndrome
Sudden severe lower abdominal pain	Ruptured ovarian cyst
Fainting with abdominal pain	Internal bleeding
Breathlessness or chest tightness	Pleural effusion or clot
Rapid weight gain over a day or two	Severe fluid shift
Passing very little urine	Severe hyperstimulation
Severe persistent nausea and vomiting	Severe hyperstimulation
Calf pain, swelling or redness	Deep vein thrombosis
Sudden one-sided weakness or slurred speech	Arterial thromboembolism
Swollen lips, tongue, face or throat	Angioedema or anaphylaxis
Widespread rash with collapse	Anaphylaxis
Early puberty signs in a treated boy	Androgen-induced precocious puberty

About hyperstimulation specifically

For boys treated for undescended testis

Why choose Hucog 5000 HP Injection

Clinical reasons a specialist may select it

When a specialist may choose something else

Situation	Likely preference	Reason
High hyperstimulation risk	GnRH agonist trigger	Shorter hormonal exposure
Allergy to urine-derived products	Recombinant choriogonadotropin alfa	Avoids urinary protein
Protocol specifies 10,000 IU	Hucog 10000 HP	Avoids combining two vials
No reliable cold chain	A lyophilised presentation	Solution needs 2 to 8 degrees
Primary ovarian failure	Donor egg pathway	hCG cannot help this cause
Weight loss sought	Diet and exercise programme	hCG is not effective for this

Storage instructions

Instruction	Detail
Temperature	Store in a refrigerator at 2 to 8 degrees Celsius
Freezing	Do not freeze; discard if frozen
Cold chain	Must stay refrigerated from pharmacy to patient
Transport	Carry in an insulated box with a cold pack
Light	Keep in the original carton, away from light
Refrigerator position	Store on a shelf, not in the door
Freezer compartment	Never place the vial against it
Before injection	Let the vial reach room temperature briefly
After opening	Follow clinic advice; do not store unused solution casually
Appearance check	Discard if cloudy, discoloured or holding particles
Children and pets	Store well out of their reach
Expiry	Do not use after the printed expiry date
Sharps	Dispose of needles in a sharps container
Disposal	Return unused vials to a pharmacy

Why this product needs the fridge but some hCG does not