Noveltreat 0.5 mg Pre-filled Pen (Semaglutide)

Noveltreat is a brand of semaglutide injection.

Semaglutide is a GLP-1 receptor agonist.

It copies a natural gut hormone called GLP-1.

It is supplied in a disposable prefilled pen.

The Noveltreat 1 pack delivers Noveltreat 1.7 per weekly dose.

It is approved in India for chronic weight management.

Use is limited to adults.

It is combined with diet and physical activity.

Sun Pharmaceutical Industries Ltd markets it.

DCGI approved it on the basis of an Indian Phase III trial.

Launch followed expiry of the semaglutide patent in India.

A prescription is required to buy it.

GLP-1 is a hormone released by the gut after eating.

It signals the brain and pancreas that food has arrived.

Natural GLP-1 breaks down within minutes.

Semaglutide is built to resist that breakdown.

This is why one injection lasts a whole week.

It acts on GLP-1 receptors in the brain.

This reduces hunger and increases fullness.

People then eat less at each meal.

It also slows the stomach emptying of food.

Slower emptying prolongs the feeling of fullness.

It increases insulin release when blood sugar is high.

It lowers glucagon release at the same time.

Weight loss follows the reduced energy intake.

The same slowing explains the nausea seen early on.

It also explains the anaesthesia precaution above.

If a step is not tolerated, it may be held four more weeks.

Noveltreat 2.4 mg is an accepted maintenance dose if 2.4 mg is not tolerated.

No starting dose is meant for long-term use.

Take the pen out of the refrigerator before use.

Look at the liquid through the window.

Use it only if it is clear and colourless.

Do not use it if you see particles.

Choose the abdomen, thigh or upper arm.

Clean the skin and let it dry.

Inject under the skin, not into muscle or vein.

Change the injection site each week.

Inject on the same day every week.

Any time of day is acceptable.

Meals do not affect the timing.

Dispose of the used pen in a sharps container.

Never share a pen with another person.

Ask a nurse to watch your first injection.

Keep a written record of each weekly date.

Personal history of medullary thyroid carcinoma.

Family history of medullary thyroid carcinoma.

Multiple endocrine neoplasia syndrome type 2.

A past serious allergic reaction to semaglutide.

A past serious reaction to any ingredient in the pen.

Do not combine it with another semaglutide product.

Do not combine it with any other GLP-1 receptor agonist.

Any thyroid lump, nodule or thyroid cancer in the family.

Any past attack of pancreatitis.

Any gallstones or gallbladder disease.

Diabetes, and every diabetes medicine you take.

Insulin or sulfonylurea use, which raise hypoglycaemia risk.

Diabetic retinopathy or any eye disease.

Kidney disease or a past episode of kidney injury.

Severe gastroparesis or other serious stomach problems.

Any heart rhythm problem or fast resting pulse.

Pregnancy, planned pregnancy or breastfeeding.

Any surgery, endoscopy or sedation that is planned.

Every other medicine, including oral contraceptives.

The injection may be given with or without food.

Eat smaller portions while your dose is rising.

Eat slowly and stop when you feel full.

Avoid very fatty, fried or spicy meals early on.

Drink fluids steadily through the day.

Vomiting and diarrhoea can cause dehydration.

Dehydration can injure the kidneys.

Limit alcohol, which adds to low blood sugar risk.

Keep eating protein and vegetables as weight falls.

Ask a dietitian to review your intake.

Confirm the carton says Noveltreat and 0.5 mg.

Confirm your prescription is for weight management.

If you have diabetes, ask whether you need Sematrinity instead.

Confirm no thyroid cancer history in you or your family.

Confirm you take no other GLP-1 medicine.

Confirm the pen stayed cold in transit.

Confirm the liquid is clear and free of particles.

Check the expiry date on the pen.

Fix your weekly injection day with your doctor.

Learn the injection technique from a nurse.

Buy a sharps container before the first dose.

Note the date of the dose before any surgery.

Agree which symptoms mean you must call at once.

Nausea and vomiting are commonest while the dose rises.

They usually ease at a steady dose.

Report any pain in the upper abdomen going to the back.

Get urgent medical help for any of these.

Sudden loss of vision in one or both eyes.

Eyesight that worsens quickly over hours or days.

Severe pain in the upper abdomen spreading to the back.

That pain with persistent vomiting, a pancreatitis sign.

Severe pain in the right upper abdomen after meals.

Yellow eyes or skin with pale stools.

Swelling of the face, lips, tongue or throat.

Difficulty breathing or a widespread hive-like rash.

Fainting, confusion or a fit from low blood sugar.

Sweating with shaking and a pounding heartbeat.

Vomiting or diarrhoea that stops you drinking.

Passing very little urine for a day.

A new lump in the neck or lasting hoarseness.

A resting pulse that stays unusually fast.

Carry the pen or its carton to hospital.

State the date of your last injection.

Say the drug stays active for about a week.

It is a once-weekly injection, not a daily one.

It is an Indian-made generic of a proven molecule.

DCGI approval followed a Phase III trial run in India.

It became available after the Indian patent expired.

A generic widens access compared with the originator.

It comes in five strengths for stepwise dosing.

Stepwise dosing reduces nausea at the start.

It is backed by a large published evidence base.

The same company also supplies the diabetes brand.

It must be injected and kept refrigerated.

It carries a boxed warning about thyroid tumours.

Nausea affects nearly half of users.

Maintenance costs roughly Rs. 96,200 a year.

Weight tends to return if treatment stops.

It is not the right brand if you have type 2 diabetes.

Diet and activity are required alongside it.

Store unused pens in a refrigerator at 2 to 8 degrees Celsius.

Do not freeze the pen at any time.

Discard a pen that has been frozen.

Keep the pen in its carton to protect it from light.

Do not store it in the freezer compartment.

Do not place it against the refrigerator cooling element.

After first use it may be kept below 30 degrees Celsius.

It may also be returned to the refrigerator after use.

Follow the carton and pack insert for the in-use period.

Carry it in a cool bag when you travel.

Keep it out of reach of children and pets.

Check the expiry date before each weekly dose.