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Happy Diwali!•Our team is celebrating the festival of lights.•You can order and pay as usual; all orders ship from 16 November.Happy Diwali!•Our team is celebrating the festival of lights.•You can order and pay as usual; all orders ship from 16 November.Happy Diwali!•Our team is celebrating the festival of lights.•You can order and pay as usual; all orders ship from 16 November.
It therefore reaches bacteria that live inside human cells.
This includes Chlamydia, Rickettsia, Coxiella, Brucella and Mycoplasma.
Penicillins and cephalosporins cannot reach these organisms.
Its second, non-antibiotic action
Doxycycline also inhibits human matrix metalloproteinases.
This gives an anti-inflammatory effect independent of bacterial killing.
This action contributes to its benefit in acne, rosacea and periodontitis.
Dosage Guide
Indication
Dose
Duration
Most susceptible infections
200 mg on day 1, then 100 mg once daily
As prescribed
Severe infections
200 mg once daily throughout
As prescribed
Uncomplicated chlamydial infection
100 mg twice daily
7 days
Non-gonococcal urethritis
100 mg twice daily
7 days
Pelvic inflammatory disease
100 mg twice daily, with other agents
14 days
Early syphilis (penicillin-allergic)
100 mg twice daily
14 days
Late latent syphilis (penicillin-allergic)
100 mg twice daily
28 days
Lyme disease, early localised
100 mg twice daily
10 to 21 days
Rocky Mountain spotted fever, typhus
100 mg twice daily
Until afebrile 3 days, minimum 7 days
Brucellosis
100 mg twice daily, with rifampicin or streptomycin
6 weeks
Acne vulgaris
50 mg to 100 mg once daily
6 to 12 weeks, then review
Rosacea
40 mg to 100 mg once daily
As prescribed
Malaria prophylaxis
100 mg once daily
Start 1 to 2 days before travel; continue 4 weeks after leaving
Cholera
300 mg as a single dose
Single dose
Anthrax post-exposure
100 mg twice daily
60 days
Missed dose
Take the missed capsule as soon as you remember.
Skip it if your next dose is due within a few hours.
Never take two capsules together to catch up.
Finish the whole prescribed course, even if you feel better early.
Overdose
Overdose mainly causes severe nausea, vomiting and abdominal pain.
Liver injury and pancreatitis have been reported after large doses.
There is no specific antidote.
Haemodialysis does not remove doxycycline usefully.
Seek medical help immediately for any suspected overdose.
How to Take It
Swallow the capsule whole. Do not open, crush or chew it.
Drink a full glass of water with it, at least 200 mL.
Stay sitting or standing upright while you take it.
Do not lie down for at least 30 minutes afterwards.
Never take it immediately before going to bed.
Take it with food or a snack to reduce stomach upset.
Take it at the same time each day.
Separate it from antacids, iron and calcium by at least 2 to 3 hours.
Complete the full course, exactly as prescribed.
Precautions
Do not take Acticycline 100 if any of the following apply.
You are allergic to doxycycline or any tetracycline antibiotic.
You are pregnant, or think you may be pregnant.
The patient is a child under 12 years of age.
You are breastfeeding.
You are taking isotretinoin, acitretin or any oral retinoid.
You have a known oesophageal stricture or obstruction.
You cannot sit or stand upright to swallow the capsule.
You have had a severe skin reaction to a tetracycline before.
Food and Drink Precautions
Item
Advice
Reason
Water
At least 200 mL with every dose
Prevents oesophageal ulceration
Food
May be taken with food
Reduces nausea; absorption falls only slightly
Milk, yoghurt, cheese
Separate by 2 hours if possible
Calcium binds doxycycline and reduces absorption
Calcium-fortified juices and plant milks
Separate by 2 hours
Same calcium binding effect
Iron tablets and iron-rich supplements
Separate by 2 to 3 hours
Iron forms an inactive chelate
Antacids with aluminium, magnesium or calcium
Separate by 2 to 3 hours
Reduces absorption significantly
Zinc and multivitamin supplements
Separate by 2 to 3 hours
Reduces absorption
Alcohol
Avoid or strictly limit
Chronic use shortens the half-life; also irritates the stomach
Grapefruit juice
No restriction
No clinically relevant interaction
Probiotic yoghurt or supplements
Separate by 2 hours
Antibiotic reduces live cultures
Before-Use Safety
Confirm each point before starting the course.
A doctor has prescribed this antibiotic for a specific infection.
I am not allergic to any tetracycline antibiotic.
I am not pregnant and not breastfeeding.
The patient is 12 years of age or older.
I am not taking isotretinoin or any oral retinoid.
I have told my doctor about my liver history.
I have told my doctor about every medicine and supplement I take.
I know to separate antacids, iron and calcium by 2 to 3 hours.
I will swallow each capsule upright with a full glass of water.
I will not lie down for 30 minutes after a dose.
I have sunscreen and will cover up outdoors.
I know the full course length and will complete it.
I know I am not taking any other doxycycline or tetracycline product.
The strip is sealed, undamaged and within its expiry date.
Side Effects
Side effect
What to do
Nausea
Take with food. Report if persistent.
Vomiting
Report if you cannot keep doses down.
Diarrhoea
Keep hydrated. Report if severe or bloody.
Upper abdominal pain or indigestion
Take with food. Report if severe.
Loss of appetite
Usually settles. Eat small, frequent meals.
Photosensitivity and easy sunburn
Use SPF 30 or higher. Cover up outdoors.
Vaginal thrush
Treat with antifungal. Tell your pharmacist.
Oral thrush or sore mouth
Report to your doctor.
Headache
Usually mild. Report if severe or persistent.
Skin rash
Stop and contact your doctor.
Drug Interactions – Avoid With
Doxycycline should not be combined with oral retinoids or methoxyflurane, and other tetracyclines or doxycycline products should be avoided to prevent duplication.
Antacids, iron, calcium, zinc, magnesium, multivitamins, sucralfate, bismuth, lanthanum, sevelamer, buffered didanosine, and magnesium-containing quinapril should be taken 2–3 hours apart from doxycycline because they reduce its absorption.
Medical supervision is required with warfarin, anticonvulsants, rifampicin, ciclosporin, methotrexate, digoxin, ergot medicines, penicillins, cephalosporins, and live oral typhoid vaccine due to potential interactions.
Oral contraceptives are generally not significantly affected, but vomiting or diarrhoea may reduce their reliability. Regular heavy alcohol use may reduce doxycycline effectiveness.
Emergency Warning Signs
Severe or worsening headache with blurred or double vision
Any sudden loss or narrowing of vision
Severe chest pain behind the breastbone, or pain on swallowing
Severe, watery or bloody diarrhoea with fever and cramps
Yellowing of the skin or eyes, or very dark urine
Severe pain in the upper abdomen spreading to the back
Widespread rash with blistering, peeling or mouth ulcers
Rash with fever and swollen glands
Swelling of the lips, tongue, face or throat
Difficulty breathing, wheezing or collapse
New muscle weakness, drooping eyelids or breathing difficulty
Unexplained bruising, bleeding, or fever with sore throat
Severe blistering sunburn after brief sun exposure
Inability to swallow or keep fluids down
Why Choose This Medicine
Broad activity against Gram-positive, Gram-negative and atypical bacteria
Reaches intracellular organisms that penicillins cannot touch
First-line therapy for Lyme disease, rickettsial fevers and chlamydia
Once-daily maintenance dosing in most indications
Oral bioavailability around 90%, close to intravenous levels
No dose adjustment required in any stage of kidney disease
The preferred tetracycline for patients on dialysis
Excellent tissue penetration, including lung, skin and prostate
Established role in acne and rosacea, with an anti-inflammatory action
Listed on the WHO Model List of Essential Medicines
Low cost and widely available
What to weigh before choosing it:
It must not be used in pregnancy or in children under 12 years.
Photosensitivity is common and needs active sun protection.
The capsule form requires a full glass of water and an upright posture.
A coated tablet form is gentler on the oesophagus if available.
It should be used only for an infection a doctor has assessed.
It is not a suitable choice for most urinary tract infections.
Confirm you are not already taking another tetracycline product.
Storage Instructions
Store below 25 °C in a dry place.
Keep capsules in the original blister strip until use.
Protect from light, heat and moisture.
Do not store in a bathroom cabinet or near a stove.
Do not refrigerate or freeze.
Keep out of the sight and reach of children.
Do not use after the printed expiry date.
Degraded tetracyclines can damage the kidney tubules.
Expired capsules must never be used, even if they look normal.
Do not use if the strip is torn, swollen or tampered with.
Do not use a capsule that is cracked, leaking or discoloured.
Return unused or expired capsules to a pharmacy for disposal.
Do not flush them or put them in household waste.
Never share leftover antibiotic capsules with another person.
Licensed pharmacist (B.Pharm) with 12+ years in clinical pharmacy and patient care. Reviews every article for evidence-based accuracy before it is published on ACTIZA Store.
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