CB-Lin 0.5 Mg (Cabergoline) Medically reviewed by Sanjay Gangani, B.Pharm, CMO & Pharmacist
Active Ingredient Cabergoline Indication Increased prolactin levels, Acromegaly Strength:- 0.5mg Packaging 2 tablets in strip Manufacturer Serum Institute India
INQUIRE ABOUT CB-Lin 0.5 Mg (Cabergoline)
What is CB-Lin 0.5 mg? CB-Lin is a prescription tablet containing 0.5 mg of cabergoline.
It is made by Serum Institute of India Pvt. Ltd.
Cabanex 1 mg is a dopamine agonist derived from ergot.
It lowers prolactin, the hormone that drives breast milk production.
Preventing breast milk immediately after delivery, when medically needed.
Suppressing milk already being produced, for medical reasons.
Use after a stillbirth or an abortion.
Treating disorders caused by too much prolactin.
Those include absent or irregular periods and lack of ovulation.
They also include milk production unrelated to feeding a baby.
It treats prolactin-secreting tumours of the pituitary gland.
It is not a general fertility drug.
It is not for women who wish to breastfeed.
It is not established as safe or effective under 16 years.
How CB-Lin Works (Mechanism of Action) The action happens in five simple steps:
The pituitary gland releases prolactin from cells called lactotrophs.
Dopamine normally holds that release in check.
Cabergoline directly stimulates dopamine D2 receptors there.
Prolactin release falls.
Milk production stops, or hormone balance is restored.
Prolactin begins to fall within about 3 hours of a dose.
The effect lasts 7 to 28 days in people with high prolactin.
It lasts 14 to 21 days in women just after childbirth.
That long action is why weekly dosing works.
Peak blood levels occur within about half an hour to 4 hours.
Its half-life is about 63 to 68 hours in healthy volunteers.
It is 79 to 115 hours in patients with high prolactin.
Steady levels are reached after about 4 weeks.
Food does not appear to affect how much is absorbed.
Dosage Guide Doses differ completely between the two uses. Follow your prescription.
Situation Labelled Dose Timing Key Note Preventing milk after delivery 1 mg, as a single dose On the first day after birth Only once vital signs are stable Suppressing milk already flowing 0.25 mg, half a tablet Every 12 hours for 2 days 1 mg in total; better tolerated High prolactin, starting dose 0.5 mg per week In one or two doses weekly For example Monday and Thursday High prolactin, increases Add 0.5 mg per week At monthly intervals Until the best response is reached High prolactin, usual dose 1 mg per week Weekly Range 0.25 mg to 2 mg per week Doses above 1 mg per week Split into two or more doses Across the week Single larger doses are less studied Maximum in any one day 3 mg Not to be exceeded Per the European label Severe liver impairment A lower dose As prescribed Levels rise in severe impairment Kidney impairment No change needed As prescribed Caution in dialysis or end-stage failure Under 16 years Not established Not applicable No safety or efficacy data Missed dose Take it when you remember Skip if the next is nearly due Never double up
How to read this table:
For high prolactin, this is a weekly medicine, not a daily one.
Half tablets are used for some doses, so the tablet is scored.
Prolactin is usually checked monthly while the dose is adjusted.
Levels usually normalise within two to four weeks of the right dose.
It may cause nausea, vomiting and stomach upset.
It may cause a drop in blood pressure on standing.
It may cause confusion, hallucinations or psychosis.
Seek medical help; treatment is supportive.
How to Take CB-Lin Take it with a meal, or just after eating.
Do not take it on an empty stomach, as it may cause nausea.
Take it on the exact days your doctor specifies.
Keep to the same days and times each week.
Use the score line if you need a half tablet.
Have your blood pressure checked in the first 3 to 4 days.
Rise slowly from sitting or lying, to avoid dizziness.
Attend all scans and blood tests your doctor arranges.
Before treatment for high prolactin:
The pituitary gland should be fully assessed first.
Pregnancy must be excluded before starting.
Long-term users need regular gynaecological checks.
Cabergoline restores ovulation, so pregnancy can occur quickly.
Use non-hormonal contraception during treatment.
Continue it for at least 4 weeks after stopping.
If planning pregnancy, stop one month before trying to conceive.
Take a pregnancy test every 4 weeks while periods are absent.
Once periods return, test if one is more than 3 days late.
Precautions Contraindications – Do Not Use CB-Lin If You Have: An allergy to cabergoline or any ergot medicine.
A history of psychosis, or a risk of psychosis after childbirth.
Pre-eclampsia or eclampsia.
High blood pressure after delivery, or uncontrolled high blood pressure.
A history of scarring of the lungs, heart lining or abdomen.
Evidence of heart valve disease on a scan before treatment.
Some labels also contraindicate it in liver insufficiency.
Conditions Needing Caution Severe heart or blood vessel disease.
Liver disease or kidney impairment.
Low blood pressure, or medicines that lower blood pressure.
Raynaud’s syndrome.
Stomach ulcers or bleeding from the gut.
Any history of serious mental illness, especially psychosis.
Lactose intolerance, as tablets of this type contain lactose.
Driving or operating machinery, because of sleepiness.
Food, Drink and Lifestyle Take it with food for all its uses.
The label says the effects of alcohol with it are unknown.
One listing advises avoiding alcohol because of dizziness.
Do not drive if you feel sleepy or have sudden sleep episodes.
Stand up slowly during the first days of treatment.
Before-Use Checklist Do you know whether your dose is weekly or a single dose?
Has an echocardiogram been arranged, if this is long-term?
Have you had any lung, heart-lining or abdominal scarring?
Have you ever had psychosis or severe mental illness?
Is your blood pressure controlled?
Could you be pregnant?
Are you using non-hormonal contraception?
Do you take any antipsychotic or anti-sickness medicine?
Do you know to take it with food?
Side Effects Frequencies come from the European label’s table.
Side Effect Frequency What It Feels Like What to Do Valve changes and related disorders Very common Often no symptoms at first Detected by scheduled heart scans Headache Very common Head pain Report severe or persistent headache Dizziness or vertigo Very common Light-headedness or spinning Rise slowly; report if severe Nausea or indigestion Very common Stomach upset Take with food Abdominal pain or gastritis Very common Stomach discomfort Report if persistent Weakness and fatigue Very common Low energy Report if severe Sleepiness Common Drowsiness in the day Do not drive if affected Low mood Common Depression Tell your doctor promptly Low blood pressure on standing Common Faintness when rising Rise slowly; have checks done Hot flushes Common Sudden warmth Usually settles Constipation or vomiting Common Bowel or stomach upset Report if persistent Breast pain Common Sore breasts Report if persistent Breathlessness or fluid by the lungs Uncommon Shortness of breath, chest pain Seek medical advice promptly Palpitations Uncommon Awareness of the heartbeat Report to your doctor Fainting or brief vision loss Uncommon Blackouts or visual changes Seek medical advice Rash or hair loss Uncommon Skin or hair changes Report to your doctor Swelling of the legs Uncommon Puffy ankles Report to your doctor Compulsive behaviours Not known Gambling, spending, eating, sexual urges Tell your doctor at once Sudden sleep onset Not known Falling asleep without warning Stop driving and tell your doctor Hallucinations or aggression Not known Seeing things, mood change Seek medical advice promptly
How common side effects are overall:
About 14% of women get side effects when stopping milk.
The commonest were low blood pressure, dizziness and headache.
With long-term treatment, about 70% report some side effect.
Dopamine agonists can cause impulse control disorders.
These include gambling, overspending and binge eating.
They also include a marked increase in sexual urges.
Patients and families should be told to watch for these.
The dose may be reduced or the medicine tapered off.
With long-term treatment, about 70% report some side effect. Should not be taken together:
Medicines that block dopamine, which cancel its effect.
Those include several antipsychotics and metoclopramide for sickness.
Macrolide antibiotics such as erythromycin, which raise its levels.
Other ergot medicines during long-term treatment.
Any medicine that lowers blood pressure.
Sedating medicines, because of added sleepiness.
Give your doctor a full list of your medicines.
Include anti-sickness and mental health medicines.
Do not start a new medicine without checking.
Emergency Warning Signs – Seek Urgent Medical Help After treatment to stop breast milk, seek help urgently for:
A severe, worsening or unrelenting headache.
Sudden visual disturbance.
Chest pain.
A seizure.
Weakness or numbness on one side, or difficulty speaking.
A sharp rise in blood pressure.
Breathlessness, a persistent cough or chest pain.
Swelling of the legs or pain in the flank or side.
Fainting or collapse.
Severe mental changes, including hallucinations.
Serious events have been reported in women stopping milk.
These include high blood pressure, heart attack, seizures and stroke.
Seizures and stroke were sometimes preceded by severe headache.
Blood pressure should be monitored carefully after treatment.
Why Choose CB-Lin 0.5 mg? Benefits when clinically appropriate:
A single 1 mg dose stopped milk in 70% to 90% of women in trials.
Its long action allows weekly dosing for high prolactin.
Prolactin usually normalises within two to four weeks.
It can restore periods, ovulation and fertility.
The tablet is scored, so half doses are straightforward.
Serum Institute of India is a large, established manufacturer.
Honest balance for the buyer:
Long-term use requires repeated heart scans.
It can cause scarring of heart valves, lungs or the abdomen.
It can cause compulsive behaviours that patients may not report.
It can lower blood pressure and cause sudden sleepiness.
High prolactin usually returns after treatment stops.
Several same-composition brands cost considerably less per tablet.
Storage Instructions Do not store above 25°C, per the European label.
Protect from moisture.
Keep tablets in the strip until use.
Keep out of the reach of children.
Check the expiry date before use.
Follow the storage statement on the Indian pack.
Return unused tablets to a pharmacy take-back scheme.
Sanjay Gangani
B.Pharm, CMO & Pharmacist
Licensed pharmacist (B.Pharm) with 12+ years in clinical pharmacy and patient care. Reviews every article for evidence-based accuracy before it is published on ACTIZA Store.
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