Apcalis Oral Jelly (Tadalafil)

What is Apcalis Oral Jelly?

What it does, and what it does not do

Regulatory status, stated for accuracy

How It Works (Mechanism of Action)

The erection pathway, step by step:

Key pharmacology points

Absorption and clearance

Dosage Guide

A doctor must set the dose. This table reflects approved tadalafil labelling.

Patient group or use	Starting dose	Maximum dose	Frequency	Does this product fit?
ED, adult men new to tadalafil	10 mg	20 mg	Once in 24 hours	No. Needs a 10 mg product first.
ED, men already tolerating 10 mg	20 mg	20 mg	Once in 24 hours	Yes. This is the fit.
ED, once daily use	2.5 mg	5 mg	Once every day	No. Wrong strength entirely.
BPH symptoms	5 mg	5 mg	Once every day	No. Wrong strength entirely.
Kidney: CrCl 30-50 mL/min	5 mg	10 mg	Once in 48 hours	No. Exceeds the maximum.
Kidney: CrCl under 30 or dialysis	5 mg	5 mg	Once in 72 hours	No. Exceeds the maximum.
Liver: mild or moderate	Doctor decides	10 mg	Once in 24 hours	No. Exceeds the maximum.
Liver: severe (Child-Pugh C)	Not recommended	Not recommended	Not applicable	No. Do not use.
On potent CYP3A4 inhibitors	Doctor decides	10 mg	Once in 72 hours	No. Exceeds the maximum.
Men over 65	No change for age alone	As above	As above	Depends on other factors.
Women, children, under-18s	Not indicated	Not indicated	Not applicable	No. Not for these groups.

How to Take It

Step-by-step:

Timing and the 36-hour window

Missed doses

Precautions

Absolute contraindications (never use)

Conditions to disclose to your doctor

Food and drink precautions

Before-use safety checklist

Side Effects

Common side effects

Rates below are from as-needed tadalafil trials versus placebo.

Side effect	Placebo	Tadalafil 10 mg	Tadalafil 20 mg
Headache	5%	11%	15%
Indigestion (dyspepsia)	1%	8%	10%
Back pain	3%	5%	6%
Muscle pain (myalgia)	1%	4%	3%
Blocked nose	1%	3%	3%
Flushing	1%	3%	3%
Pain in an arm or leg	1%	3%	3%

Understanding the back and muscle pain

Less common and rare side effects

Body system	Reported effects
Heart and circulation	Chest pain, palpitations, fast heartbeat, low blood pressure, fainting
Serious cardiovascular (rare)	Heart attack, sudden cardiac death, stroke
Eyes	Blurred vision, colour vision change, eye pain, eyelid swelling, conjunctivitis
Eyes (rare, serious)	NAION, visual field defect, retinal vein or artery occlusion
Ears	Ringing in the ears, sudden decrease or loss of hearing
Nervous system	Dizziness, vertigo, insomnia, numbness, migraine, seizure, transient amnesia
Digestive	Dry mouth, nausea, vomiting, reflux, gastritis, abnormal liver blood tests
Musculoskeletal	Joint pain, neck pain, muscle spasm
Urinary and genital	Prolonged erection, priapism, spontaneous erection, renal impairment
Respiratory	Shortness of breath, nosebleed, sore throat
Skin and allergy	Rash, itching, sweating, hives
Skin (rare, serious)	Stevens-Johnson syndrome, exfoliative dermatitis

Drug Interactions – Avoid With

Risk level	Drug or substance	What happens
NEVER COMBINE	All organic nitrates: nitroglycerin, isosorbide mono/dinitrate	Severe, possibly fatal blood pressure drop
NEVER COMBINE	Nitrite poppers: amyl nitrite	Severe, possibly fatal blood pressure drop
NEVER COMBINE	Riociguat and other guanylate cyclase stimulators	Blood pressure may fall to an unsafe level
NEVER COMBINE	Other PDE-5 inhibitors: sildenafil, vardenafil	No added benefit; blood pressure falls further
NEVER COMBINE	Other tadalafil products, including the lung-pressure brand	Accidental double dosing
DOSE PROBLEM	Ketoconazole 400 mg daily	Tadalafil exposure rises 312%; 20 mg exceeds the limit
DOSE PROBLEM	Ritonavir 200 mg twice daily	Tadalafil exposure rises 124%; 20 mg exceeds the limit
DOSE PROBLEM	Itraconazole and other potent CYP3A4 inhibitors	Maximum allowed is 10 mg per 72 hours
USE WITH CAUTION	Alpha-blockers: doxazosin, tamsulosin, alfuzosin	Dizziness, fainting, symptomatic low blood pressure
USE WITH CAUTION	Blood pressure medicines and angiotensin II receptor blockers	Additional fall of roughly 8/4 mmHg
USE WITH CAUTION	Alcohol, 5 units or more	Dizziness, headache, orthostatic low blood pressure
REDUCED EFFECT	Rifampicin	Tadalafil exposure falls by 88 percent
REDUCED EFFECT	Carbamazepine, phenytoin, phenobarbital	Tadalafil exposure likely falls
MINOR	Antacids	Absorption slows, but total exposure is unchanged
MINOR	Grapefruit juice (raises levels)	May increase side effects

Emergency Warning Signs

Stop the medicine and get emergency medical care if any of these occur:

Why Choose Apcalis Oral Jelly

Storage Instructions

Medical Disclaimer