TADAGA ORAL JELLY (Tadalafil)

Tadaga Oral Jelly is a prescription medicine for erectile dysfunction.

Each sachet contains 20 mg of the active ingredient tadalafil.

Tadalafil belongs to the PDE-5 inhibitor drug class.

The medicine is a flavoured gel supplied in single-dose sachets.

It suits men who dislike swallowing tablets.

Packs commonly hold seven sachets in assorted flavours.

RSM Enterprises lists this product on its own website.

Other retailers name RSM Multilink LLP or Samok Overseas.

The same molecule is sold as Cialis in a swallowed tablet.

Tadaga 10 mg helps men achieve and maintain a firm erection.

It works only when you are sexually aroused.

It does not increase sexual desire or libido.

It does not change testosterone or oestrogen levels.

It does not protect against HIV or other sexually transmitted infections.

Sexual stimulation triggers the release of nitric oxide in penile tissue.

Nitric oxide raises levels of a messenger called cyclic GMP (cGMP).

Cyclic GMP relaxes the smooth muscle inside the corpus cavernosum.

Relaxed muscle allows more blood to flow into the penis.

Increased blood flow produces and maintains a firm erection.

An enzyme called PDE-5 normally breaks down cGMP.

Tadalafil selectively blocks the PDE-5 enzyme.

Blocking PDE-5 keeps cGMP levels higher for longer.

Blood vessels stay relaxed and erection quality improves.

Without sexual stimulation, tadalafil produces no erection.

Peak blood levels occur between 30 minutes and 6 hours.

The median time to peak level is about 2 hours.

Elimination half-life is approximately 17.5 hours.

Clinical effect can last up to 36 hours.

The liver enzyme CYP3A4 is the main metabolism pathway.

Excretion occurs mainly through faeces and partly through urine.

A jelly is already dispersed, so no tablet must break down first.

That could in principle shorten the time to absorption.

The FDA label describes tadalafil as practically insoluble in water.

A poorly soluble drug is a difficult candidate for a gel base.

No regulator has published data on tadalafil jelly absorption.

Every dose shown is from the approved tadalafil prescribing information.

All approved figures apply to swallowed film-coated tablets.

Several patient groups are limited to 5 mg or 10 mg.

A patient in any of those groups should not take 20 mg.

Your doctor decides whether this product suits you at all.

Never raise your own dose because a lower dose felt weak.

This medicine is taken as needed, so missed doses rarely apply.

Never take two tablets to make up for one.

Never exceed one tablet in 24 hours.

Do not combine it with any other tadalafil product.

Contact a doctor or poison centre immediately after a suspected overdose.

Confirm with your doctor that this product is right for you.

Ask whether an approved swallowed tablet would suit you better.

Check the sachet and reject any that is split or leaking.

Read the instruction printed on your own pack first.

Use one whole sachet and never part of one.

Squeeze the contents into the mouth as the pack directs.

Use the sachet immediately once it is opened.

Take it about 30 to 60 minutes before sexual activity.

Wait for sexual stimulation, as the tablet alone will not work.

Allow at least 24 hours between two doses.

Do not combine it with any other ED medicine.

Effects from tadalafil can persist for up to 36 hours.

Side effects may also persist across that whole period.

Keep alcohol intake low to avoid dizziness and low blood pressure.

Rise slowly from sitting or lying for the first few hours.

Avoid driving until you know how the dose affects you.

Stop sexual activity and seek help if chest pain occurs.

Tell your doctor if erections remain poor after several attempts.

Take any nitrate medicine, regularly or occasionally.

Use nitroglycerin, isosorbide mononitrate or isosorbide dinitrate.

Use recreational nitrites known as “poppers” (amyl or butyl nitrite).

Take riociguat or another soluble guanylate cyclase stimulator.

Are allergic to tadalafil or any tablet ingredient.

Had a serious hypersensitivity reaction to tadalafil before.

Had a heart attack within the last 90 days.

Had a stroke within the last six months.

Have unstable angina or angina during sexual intercourse.

Have uncontrolled high or very low blood pressure.

Have severe heart failure or uncontrolled irregular heartbeat.

Were told that sexual activity is unsafe for your heart.

Any heart disease, chest pain, valve problem or past bypass surgery.

High blood pressure or low blood pressure.

Kidney disease or a history of dialysis.

Liver disease, hepatitis or cirrhosis.

Diabetes, especially if it is poorly controlled.

Phenylketonuria, since flavoured jellies may contain aspartame.

Any mouth ulcer, gum disease or dry mouth condition.

Stomach ulcers or any bleeding disorder.

Sickle cell anaemia, leukaemia or multiple myeloma.

Any penile deformity, such as Peyronie’s disease or curvature.

A previous erection lasting more than four hours.

Retinitis pigmentosa or any inherited eye disease.

Sudden vision loss or hearing loss in the past.

Food does not meaningfully change absorption of swallowed tadalafil.

Do not keep a partly used sachet for later.

Swallowing liquid too soon may wash the dose down the throat.

Avoid grapefruit and grapefruit juice while using this medicine.

Grapefruit can raise tadalafil blood levels and side effect risk.

Limit alcohol, as it worsens dizziness and lowers blood pressure.

Five or more alcohol units raise the risk of fainting.

Avoid pomelo juice and Seville orange products as a precaution.

Check the sweetener and sugar content if you have diabetes.

Has a doctor prescribed this form and strength for you?

Does your pack state clearly how the jelly should be taken?

Have you confirmed you take no nitrate medicine of any type?

Have you confirmed you do not take riociguat?

Has your doctor confirmed your heart can handle sexual activity?

Have you listed all your medicines for the doctor or pharmacist?

Have you disclosed any kidney or liver disease?

Have you checked you take no antifungal or HIV medicine?

Have you checked you took no other ED tablet in 24 hours?

Have you checked the expiry date and the blister condition?

No trial has measured side effect rates for a tadalafil jelly.

Local mouth effects are not documented in any approved label.

Headache rose from 11% at 10 mg to 15% at 20 mg.

Indigestion rose from 4% at 5 mg to 10% at 20 mg.

This list is not complete; report any unusual symptom.

Report suspected reactions to your national pharmacovigilance programme.

Nitrates: nitroglycerin, isosorbide mononitrate, isosorbide dinitrate.

Nitrate sprays, patches, ointments and sublingual tablets.

Recreational nitrites, commonly sold as “poppers”.

Riociguat and other guanylate cyclase stimulators.

Other PDE-5 inhibitors: sildenafil, vardenafil, avanafil.

Any other tadalafil product, including daily-dose and PAH brands.

Alpha-blockers: doxazosin, tamsulosin, alfuzosin, terazosin.

Blood pressure medicines, including amlodipine and enalapril.

Diuretics such as bendroflumethiazide.

Strong CYP3A4 inhibitors: ketoconazole, itraconazole, ritonavir.

Macrolide antibiotics such as clarithromycin and erythromycin.

CYP3A4 inducers: rifampicin, phenytoin, carbamazepine, phenobarbital.

St John’s wort, which can reduce the medicine’s effect.

Alcohol in large amounts, due to added blood pressure drop.

Grapefruit juice, which can raise tadalafil blood levels.

Nitrates plus tadalafil can cause a dangerous fall in blood pressure.

At least 48 hours must pass before any nitrate is given.

Alpha-blockers plus tadalafil can cause fainting on standing.

Ketoconazole raised 20 mg tadalafil exposure by over 300%.

The approved limit with such a drug is 10 mg in 72 hours.

CYP3A4 inducers lower tadalafil levels and reduce effectiveness.

Interaction data were gathered using swallowed tablets only.

An erection lasting longer than four hours (priapism).

A painful erection of any duration.

Sudden loss of vision in one or both eyes.

Sudden decrease or loss of hearing, with or without ringing.

Chest pain, pressure or tightness during or after sex.

Pain spreading to the jaw, neck, shoulder or left arm.

Severe dizziness, fainting or collapse.

Shortness of breath at rest or with light effort.

Irregular, racing or pounding heartbeat.

Swelling of the face, lips, tongue or throat.

Swelling or blistering inside the mouth.

Widespread rash, hives or difficulty breathing or swallowing.

Blistering or peeling skin anywhere on the body.

Seizure or sudden confusion.

Numbness or weakness on one side of the body.

Long action window of up to 36 hours after one dose.

Flexible timing removes the pressure of a narrow dosing window.

Tadalafil is backed by large, long-running clinical trial data.

Well-defined safety profile documented in regulatory labels.

Generic pricing makes treatment more affordable.

The jelly format suits men who dislike swallowing tablets.

Single-dose sachets are discreet and easy to carry.

Blister packaging protects each tablet from moisture.

No regulator has approved a tadalafil oral jelly product.

Faster onset from the jelly is not supported by published data.

How much drug is absorbed from the jelly has not been measured.

Listings disagree on how the product should even be taken.

Tadalafil is described in the label as practically insoluble in water.

An approved swallowed 20 mg tablet has full published evidence.

Tadalafil is not approved to treat premature ejaculation.

It does not raise testosterone or lower oestrogen.

Tadalafil does not cure erectile dysfunction.

ED can signal heart disease or diabetes, so get assessed.

A valid prescription and medical review remain essential.

Store at controlled room temperature, ideally 20°C to 25°C.

Brief excursions between 15°C and 30°C are acceptable.

Keep every tablet sealed in its original blister until use.

Dissolving tablets absorb moisture quickly once exposed.

Do not store loose tablets in a pill box or pouch.

Protect from direct sunlight, heat and humidity.

Do not store in the bathroom or near a sink.

Do not refrigerate or freeze the tablets.

Examine the blister and reject any that is torn or empty.

Keep the pack out of sight and reach of children.

Keep away from pets at all times.

Check the expiry date printed on the blister and carton.