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Kamagra Oral Jelly Vol. 2 (Sildenafil Citrate)

Medically reviewed by Sanjay Gangani, B.Pharm, CMO & Pharmacist

Active Ingredient Sildenafil Citrate
Indication Erectile Dysfunction
Manufacturer Ajanta Pharma Ltd
Packaging 7 x 5g Sachets in Box

Kamagra Oral Jelly Vol. 2 (Sildenafil Citrate)

Pack Size Price Price/unit Quantity Add To Cart
28 Sachet/s $55 $1.96/Pill
56 Sachet/s $94 $1.68/Pill
84 Sachet/s $125 $1.49/Pill

What is Kamagra Oral Jelly Vol. 2?

  • Kamagra Oral Jelly Vol. 2 is a prescription medicine for erectile dysfunction.

  • It treats ED in adult men only.

  • Each 5 g sachet delivers sildenafil citrate equal to 100 mg sildenafil.

  • Ajanta Pharma Ltd., India, manufactures the Kamagra range.

  • The product is a soft, sweet, flavoured gel in a sealed sachet.

  • Vol. 2 is a second flavour assortment of the same jelly (trade listing).

  • It is swallowed straight from the sachet. No water is needed.

  • Sildenafil belongs to the PDE-5 inhibitor drug class.

  • It helps a man get and keep an erection during sexual stimulation.

  • It does not cause an erection on its own.

  • Sexual arousal is always required for the medicine to work.

  • It is not a hormone, an aphrodisiac, or a fertility treatment.

  • It is not for women or for anyone under 18 years.

  • It gives no protection against HIV or other sexually transmitted infections.

Regulatory status (stated for accuracy)

  • Sildenafil citrate is an approved molecule in India, the US, the UK and the EU.

  • The Kamagra brand itself is licensed in India.

  • Kamagra 100 is not approved by the US FDA, the EMA, or the UK MHRA.

  • Counterfeit Kamagra oral jelly is widely reported online. Buy only from a licensed pharmacy.

How It Works (Mechanism of Action)

The erection pathway, step by step:

  • Sexual stimulation releases nitric oxide (NO) into the penile tissue.

  • Nitric oxide switches on the enzyme guanylate cyclase.

  • Guanylate cyclase raises levels of cyclic guanosine monophosphate (cGMP).

  • cGMP relaxes the smooth muscle of the corpus cavernosum.

  • Relaxed muscle lets more blood flow into the penis.

  • The enzyme PDE-5 normally breaks cGMP down and ends the erection.

  • Sildenafil blocks PDE-5, so cGMP stays higher for longer.

  • The result is a firmer erection that lasts longer during arousal.

Key pharmacology points

  • Sildenafil has no direct relaxant effect on penile tissue by itself.

  • At normal doses it has no effect without sexual stimulation.

  • Sildenafil is about 4,000 times more selective for PDE-5 than PDE-3.

  • PDE-3 controls heart muscle contraction. High selectivity limits cardiac effects.

  • Sildenafil is only about 10 times more selective for PDE-5 than PDE-6.

  • PDE-6 sits in the retina. This explains temporary blue-green colour changes.

Absorption and clearance

  • Absorption is rapid. Peak level occurs in 30 to 120 minutes (median 60).

  • Mean absolute bioavailability is about 41 percent.

  • Sildenafil and its active metabolite have a half-life of about 4 hours.

  • The liver clears it, mainly through the enzyme CYP3A4.

  • About 80 percent leaves in the faeces and about 13 percent in urine.

Dosage Guide

A doctor must set the dose. The table below reflects approved sildenafil labelling.

Patient groupStarting doseMaximum doseFrequencyKey note
Adult men 18-64, otherwise healthy50 mg100 mgOnce in 24 hoursTake 30–60 minutes before sex
Men aged 65 and above25 mgDoctor decidesOnce in 24 hoursBlood levels run higher in older men
Severe kidney impairment (CrCl under 30 mL/min)25 mgDoctor decidesOnce in 24 hoursDrug exposure roughly doubles
Any degree of liver impairment25 mgDoctor decidesOnce in 24 hoursClearance is reduced
Men stable on an alpha-blocker25 mgDoctor decidesOnce in 24 hoursBe stable on the alpha-blocker first
On erythromycin or strong CYP3A4 inhibitors25 mgDoctor decidesOnce in 24 hoursKetoconazole, itraconazole, saquinavir
On ritonavir25 mg25 mgOnce in 48 hoursRitonavir raises sildenafil levels 11-fold
Women, children, under-18sNot indicatedNot indicatedNot applicableNot for use in these groups

How to Take It

Step-by-step:

  • Confirm your dose and suitability with a registered doctor.

  • Check the sachet seal and the printed expiry date.

  • Tear the sachet open along the notched edge.

  • Squeeze the full contents into your mouth, or onto a spoon.

  • Swallow the jelly directly. Water is not required.

  • Take it 30 to 60 minutes before planned sexual activity.

  • Allow sexual stimulation to occur. Arousal is essential.

  • Use one sachet only. Discard any unused jelly.

  • Do not take another dose within 24 hours.

Timing, food and missed doses

  • The usual effect window is about 4 hours.

  • Dosing may be done from 30 minutes up to 4 hours before activity.

  • An empty stomach gives the fastest onset.

  • A high-fat meal delays the peak level by about 60 minutes.

  • A high-fat meal also lowers the peak level by about 29 percent.

  • This medicine is taken only as needed.

  • There is no fixed schedule, so there is no missed dose to make up.

  • Never double a dose for any reason.

  • If you take too much, go to a hospital emergency department.

Precautions

Absolute contraindications (never use)

  • Any nitrate medicine, in any form, regular or occasional.

  • Examples: nitroglycerin, isosorbide mononitrate, isosorbide dinitrate.

  • Nitric oxide donors such as sodium nitroprusside.

  • Recreational nitrite ‘poppers’, including amyl nitrite and butyl nitrite.

  • Guanylate cyclase stimulators such as riociguat.

  • Known allergy to sildenafil or to any ingredient in the jelly.

  • Men for whom sexual activity is unsafe due to heart disease.

  • Use in women, or in anyone under 18 years of age.

Conditions to disclose to your doctor

  • Heart attack, stroke, or dangerous irregular heartbeat in the last 6 months.

  • Angina, heart failure, or heart surgery within the last 6 months.

  • Narrowing of the aortic valve, or other outflow obstruction.

  • Low blood pressure, or high blood pressure that is not controlled.

  • A curved or deformed penis, such as Peyronie’s disease.

  • Any past erection lasting more than 4 hours.

  • Sickle cell anaemia, multiple myeloma, or leukaemia.

  • Retinitis pigmentosa, an inherited eye disease.

  • Any past severe vision loss, especially NAION.

  • Bleeding disorders, or an active stomach ulcer.

  • Liver disease, kidney disease, or dialysis treatment.

  • All current medicines, including herbal and over-the-counter products.

Food and drink precautions

  • Avoid grapefruit and grapefruit juice. It may raise sildenafil levels.

  • Limit alcohol. Alcohol can worsen dizziness and low blood pressure.

  • Alcohol also reduces erectile response on its own.

  • Avoid a heavy, high-fat meal in the hour before your dose.

  • A light meal or an empty stomach is preferred.

  • Avoid recreational drugs, especially nitrite poppers.

Before-use safety checklist

  • Do I hold a valid prescription from a registered doctor?

  • Have I confirmed that I take no nitrate medicine of any kind?

  • Am I free of poppers and other nitric oxide donors?

  • Has my doctor confirmed my heart can handle sexual activity?

  • Have I given my doctor a full list of my medicines?

  • Have I declared any liver, kidney, eye or blood conditions?

  • Is the sachet sealed, undamaged, and within its expiry date?

  • Has it been more than 24 hours since my last dose?

  • Do I know the emergency warning signs in Section 8?

Side Effects

Common side effects

Rates below are from fixed-dose sildenafil trials at 100 mg versus placebo.

Side effectAt 100 mg doseOn placebo
Headache28%7%
Flushing (warm, red face)18%2%
Indigestion (dyspepsia)17%2%
Vision changes (blue tinge, glare, blurring)11%1%
Blocked or runny nose9%2%
Back pain4%2%
Muscle pain (myalgia)4%1%
Nausea3%1%
Dizziness3%2%
Skin rash3%1%
  • Most common effects are mild and short-lived.

  • Vision changes are usually mild, temporary, and dose-related.

  • In trials, only 2.5% of men stopped treatment due to side effects.

  • The placebo stop rate was 2.3%, which is almost the same.

Less common and rare side effects

Body systemReported effects
Heart and circulationPalpitations, fast heartbeat, low blood pressure, fainting, chest pain
Serious cardiovascular (rare)Heart attack, dangerous rhythm, stroke, sudden cardiac death
EyesEye pain, red eyes, light sensitivity, double vision, retinal bleeding
Eyes (rare, serious)NAION – sudden vision loss in one or both eyes
EarsRinging in the ears, sudden decrease or loss of hearing
Nervous systemTremor, numbness, insomnia, anxiety, seizure, transient global amnesia
DigestiveVomiting, dry mouth, diarrhoea, abnormal liver blood tests
Urinary and genitalProlonged erection, priapism, blood in urine, abnormal ejaculation
RespiratoryNosebleed, shortness of breath, sinus inflammation, cough
Skin and allergyHives, itching, sweating, contact dermatitis, allergic reaction

Drug Interactions – Avoid With

Risk levelDrug or substanceWhat happens
NEVER COMBINEAll nitrates: nitroglycerin, isosorbide mono/dinitrateSevere, possibly fatal blood pressure drop
NEVER COMBINENitrite poppers: amyl nitrite, butyl nitriteSevere, possibly fatal blood pressure drop
NEVER COMBINERiociguat and other guanylate cyclase stimulatorsAdded blood-pressure lowering effect
NEVER COMBINEOther PDE-5 inhibitors: tadalafil, vardenafilNo added benefit; blood pressure falls further
NEVER COMBINEOther sildenafil products, e.g. Revatio for lung pressureAccidental double dosing
DOSE ADJUSTMENT NEEDEDRitonavir and other HIV protease inhibitorsSildenafil level rises up to 11-fold
DOSE ADJUSTMENT NEEDEDKetoconazole, itraconazole, saquinavirStrong CYP3A4 block raises drug levels
DOSE ADJUSTMENT NEEDEDErythromycin, clarithromycinSildenafil exposure rises about 3-fold
DOSE ADJUSTMENT NEEDEDCimetidineSildenafil level rises about 56 percent
USE WITH CAUTIONAlpha-blockers: doxazosin, tamsulosin, terazosin, alfuzosin, silodosinDizziness, fainting, symptomatic low blood pressure
USE WITH CAUTIONBlood pressure medicines, including amlodipineExtra fall of about 8/7 mmHg
USE WITH CAUTIONBlood thinners, in men with bleeding disordersSafety not established
REDUCED EFFECTBosentanSildenafil exposure falls about 63 percent
REDUCED EFFECTRifampicin and other strong CYP3A4 inducersSildenafil level falls; medicine may not work
REDUCED EFFECTGrapefruit juice (opposite direction – raises levels)May increase side effects

Emergency Warning Signs

Stop the medicine and get emergency medical care if any of these occur:

  • An erection lasting more than 4 hours. This is priapism.

  • Untreated priapism can permanently damage penile tissue.

  • Sudden loss of vision in one or both eyes.

  • Sudden decrease or loss of hearing, with or without ringing.

  • Chest pain, pressure, or pain spreading to the arm, neck or jaw.

  • Chest pain, dizziness or nausea during sex. Stop the activity at once.

  • Fainting, or severe dizziness on standing.

  • Slurred speech, facial droop, or one-sided weakness.

  • Swelling of the lips, tongue, face or throat.

  • Difficulty breathing or swallowing, or widespread hives.

  • A seizure.

Why Choose Kamagra Oral Jelly Vol. 2

  • No water needed. The jelly is swallowed straight from the sachet.

  • A practical option for men who dislike swallowing tablets.

  • Vol. 2 offers a different seven-flavour assortment (trade listing).

  • Single-use sachets are compact, sealed and discreet to carry.

  • Each sachet is pre-measured, so no dose counting is needed.

  • Contains sildenafil, the most studied ED molecule since 1998.

  • In trials, 82% of men on 100 mg reported improved erections.

  • Only 24% reported improvement on placebo.

  • Sildenafil also worked in men with diabetes-related ED.

  • It worked in men after spinal cord injury and radical prostatectomy.

  • Made by Ajanta Pharma Ltd., a listed Indian pharmaceutical company.

Storage Instructions

  • Store at room temperature, 20 °C to 25 °C (68 °F to 77 °F).

  • Short excursions from 15 °C to 30 °C are acceptable.

  • Keep each dose in its sealed original sachet until use.

  • Protect from direct sunlight, heat and moisture.

  • Do not refrigerate and do not freeze.

  • Do not store in a bathroom cabinet or a parked car.

  • Keep out of the sight and reach of children.

  • Discard any opened or part-used sachet. Do not save it.

  • Do not use after the printed expiry date.

  • Dispose of unused medicine through a pharmacy take-back scheme.

  • Never share this medicine with another person.

Medical Disclaimer

  • This content is for general information only.

  • It does not replace advice from a qualified doctor or pharmacist.

  • Sildenafil is a prescription-only medicine.

  • Do not self-prescribe or change a dose without medical advice.

  • Product details such as flavour and pack size may vary by batch and market.

  • Always read the leaflet supplied with the product you receive.

Sanjay Gangani

Sanjay Gangani

B.Pharm, CMO & Pharmacist

Licensed pharmacist (B.Pharm) with 12+ years in clinical pharmacy and patient care. Reviews every article for evidence-based accuracy before it is published on ACTIZA Store.

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